Study of Serum Prolactin and Serum Uric Acid Level in Evaluating the Cardiovascular Risks in Ckd Patients

Jayakala P and Monika .

Published on: 2023-11-21

Abstract

Introduction: Chronic kidney disease (CKD) is characterized by irreversible loss of renal function leading to excretory, metabolic, and synthetic failure culminating in accumulation of non-protein nitrogenous substances and present with varied clinical manifestations.

Prolactin (PRL) is a hormone secreted mainly by anterior pituitary gland. Hyperprolactinemia in CKD is the consequence of both reduced prolactin clearance and increased production and also its biological activity is increased. Elevsated levels of serum prolactin which occurs in CKD may contribute to vascular derangements associated with endothelial dysfunction. Several studies conducted recently are showing that prolactin may have several biologic actions that participate in the atherosclerotic process and leads to insulin resistance.
Aims and Objective: To study the level of serum prolactin, Lipid profile and Serum Uric acid levels in chronic kidney disease (CKD).

Material and Methods: The study was conducted in 40 CKD patients compared with 40 apparently healthy controls. Fasting serum prolactin level was measured in a fully automated hormone analyser based on chemiluminescent immunoassay. The blood urea, serum creatinine and serum uric acid levels were analysed to study the renal status along with routine blood sugar by standard kit methods.

Results and Conclusion: Among the 40 CKD patients, the serum prolactin level was elevated significantly and also the serum urea, creatinine, serum uric acid, Lipid profile were elevated due to irreversible loss of renal function and due to endothelial dysfunction. The levels are within normal range in the control group.