Clinical Efficacy of Music Therapy for Children with Autism Spectrum Disorder (ASD) By Bioresonance Measurement

Fukuda Y, Nose H, Morishima A and Bando H

Published on: 2024-09-05

Abstract

Autism spectrum disorders (ASD) often cause difficulties in social and everyday life throughout a person's life. Children with ASD (n=10) were medically evaluated between pre- and post-music therapy using bioresonance measurement. As a result, the average value of oxytocin showed significant reduction of 5.0 to 3.8 (p<0.01). Other 6 factors did not show significant changes, including GABA, Ach, serotonin, dopamine, autonomic nerve and ASD. Among 10 cases, 8 cases showed improvement of value after music therapy. For treatment of ASD, intranasal oxytocin administration has been tried with clinical efficacy. This report hopefully becomes beneficial reference for future practice and research.

Keywords

Autism spectrum disorders (ASD); Music therapy; Bioresonance; Oxytocin; Intranasal oxytocin; Integrative medicine (IM)

Introduction

Autism spectrum disorders (ASD) often cause difficulties in social and everyday life throughout a person's life [1]. Communication disorders due to ASD limit the ability to understand what is happening around oneself and make it difficult to respond appropriately to people and situations [2]. In terms of sociality, even the simplest interactions with people involved cause problems. Furthermore, there is a strong attachment to specific interests and fixed lifestyles, and a poor ability to respond to people's facial expressions and tones of voice disrupt daily life. This is why ASD cases are said to have behavioral disorders. The treatment direction would be to reduce core symptoms and also related symptoms, and to improve QOL for the patient and also family [3].

On the other hand, music has been believed to have the power to influence human heart [4]. Recently, music therapy can be used for not only older patients for anti-aging therapy, but also children for psychological problems [5]. Authors have continued practice and research of music therapy session for children and older patients with various problems [6,7].

Previously, the authors have published various reports in the broad field of integrative medicine (IM), including research on Ayurveda [8], music therapy practice [9], and the use of bioresonance [10]. In recent years, research on music therapy for ASD has also been reported [11]. We have also reported the results of examining cases of ASD and their mothers [10]. By combining the various axes mentioned here, we have currently provided music therapy to cases of ASD and perform a detailed examination using bioresonance measurement. The general outline and some perspectives are described in this article.

Subjects and Methods

The subjects in the current study were ten children (M/F 9/1, 5-12 years old, 8.1 years in average who were diagnosed as Autism Spectrum Disorder (ASD). The methods included the session of music therapy were provided to the applicants. As the general outline of the session, they had about 30 minutes active style of music therapy twice during one month. Concerning the protocol, buccal mucosal cells of the applicants were collected by using the dedicated kit before the first session and after the second session, and measurements were conducted by the standard apparatus of Vibration Medicine Bioresonance [12]. Buccal mucosal cells were taken by the parent of the child in the waiting room adjacent to the session room. As the reason, this procedure can bring emotional instability of the cases with ASD.

Bioresonance measurements were conducted using the standard medical device, Rayocomp (Rayonex company, Germany) (Figure 1)[13].?Measurements and resonance response testing evaluation were performed [14]. The items were autism, autonomic nerves, and brain neurotransmitter hormones (dopamine, serotonin, acetylcholine, GABA, oxytocin).?The results of the bioresonance reaction are evaluated on a 6-point scale. Normal is 1 or 2, and above is 3, 4, 5, or 6. The details are 1=very good, 2=good, 3=mild, 4=moderate, 5= severe, and 6=extremely bad [15].

Figure 1: The Apparatus for Bioresonance Measurement.

Ethical Considerations

This study was conducted with Declaration of Helsinki. Furthermore, certain commentary was presented from the Ethical Guidelines for Research for Humans, that is related with Good Clinical Practice (GCP). Authors established the committee for managing ethical considerations. The members discussed in the satisfactory situation and agreed the current protocol. Thorough explanation was provided for the subjects’ guardians concerning the detail information of the research protocol. Their consent was taken for the document.

Results

From the bioresonance measurement by the medical apparatus, data of before and after music therapy session were obtained concerning 7 factors (Figure 2). Among them, oxytocin showed remarkable reduction of 5.0 to 3.8 which showed significant difference (p<0.01). Other 6 factors did not show significant changes between pre- and post- music therapy session, which included GABA, Ach, serotonin, dopamine, autonomic nerve and artism.

Only oxytocin showed significant reduction after music therapy session. Then, the change in oxytocin for each case was shown in Figure 3. Eight out of 10 cases showed improvement in oxytocin.

Figure 2: The Results of Bioresonance Measurement for 7 Factors.

Figure 3: The Results of Changes in Oxytocin for 10 Applicants.

Discussion

ASD has been recognized for a neurodevelopmental disorder [16]. It has several symptoms related to communication and language, that are encompassed as a continuum of various situations [17]. Their characteristics show rather wider diagnosis and symptoms, including broad autistic spectrum.

The core symptoms usually show persistent difficulty with inter-personal communication, special interests, limited mobility and repetitive behaviors [18]. Autism spectrum cases often feel very anxious when their usual habits are interrupted.

The principle of bioresonance has certain frequency [13]. In the complementary and alternative medicine (CAM), this treatment was established by the engineer Paul Schmidt. In 1975, he discovered the fact that not only frequency spectrum of the sun, but also other frequency spectra had certain effects on human body. After that, bioresonance method has been based on stimulating the organism with supporting self-regulation. Among various medical and health problems, patients with cervical spine syndrome (CSS) were reported to show clinical efficacy with pain reduction. So far, bioresonance treatment can relieve symptoms and give novel sensation of physical well-being [19].

Some recent reports can be found concerning music therapy and ASD. Clinical efficacy of music therapy for ASD cases was studied. They included 165 cases from 10 reports. Music therapy showed superiority with higher standardised mean difference (SMD), for 0.41 for social adaptation, 0.96 for joy, and 0.82 for quality of parent-child relationships [20]. Recent study showed the effect of music therapy for ASD children. From 18 RCT (n=1457), improvement was observed in language communication, social skills, behavior, sensory perception and self-help [21]. For children with ASD, music therapy can contribute the improvement of their ability for communication and expression [22]. They plan to commence the protocol of Music for Autism trial which includes comprehensive framework for multidimensional aspects.

In the current results of the study, significant changes in oxytocin were found between pre- and post-music therapy presentation. From genetic points of view, common variants of specific oxytocin-related genes (OTRGs) are reported to have relation with ASD etiology [23]. Investigating ASD cases vs control (n=15581 vs 3391), genetic OTRG variations were detected concerning meaningful relationship with the onset of ASD. As a result, common order seemed to be dnCNVs > ihCNVs > DNMs, in which about 10-11% would be accounted for probands with rare disruptive variations among all probands of ASD.

In the light of hormonal function, oxytocin and serotonin can modulate human neural function together [24]. Historically, intranasal oxytocin administration has been tried and continued so far [25]. The protocol was the comparison of clinical changes for ASD cases (n=40) with intranasal oxytocin and control groups. The results in the former group presented significant improvements of the response time for nonverbal information-based judgments (NVJs) (p=0.02), positive difference for NVJs|(p=0.03), and activity of medical prefrontal cortex in the brain (p<0.001). Then, oxytocin showed neurobiological benefit for sociocommunicational deficits of ASD [26].

Some limitation exists in this study. The number of the cases with ASD was small, and the protocol was not so long or complicated. The method seemed to be adequate for medical evaluation. Then, related research will be continued for the well-being of the ASD cases.

In summary, current research was performed for ASD children associated with the evaluation of bioresonance measurement. Current results with research methodology is expected to become useful reference for future development of clinical beneficial practice.

Conflict of interest

The authors declare no conflict of interest.

Funding

There was no funding received for this paper.

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