Cytokine Levels in Thromboangiitis Obliterans Patients with Amputation

Darvishvand R, Ghasemi Z, Faghih A, Johari HG and Talepoor AG

Published on: 2024-09-19

Abstract

Background: Thromboangiitis obliterans (TAO), or Buerger's disease, is characterized by non-atherosclerotic vasculitis mostly in young males. Cytokines as signaling proteins play a vital role in the pathogenesis of TAO.

Methods: We evaluated the serum levels of 7 cytokines in TAO patients with amputation (n= 20), high-stenosis patients (n= 20), smokers healthy individuals (n= 20) and non-smoker healthy controls (n= 20).

Results: Our results indicated that the mean (± SEM) serum levels of IL-1β (P < 0.0001), IL-6 (P < 0.0001), IL-18 (P < 0.0001), IFN-γ (P < 0.0001), IL-12 (P < 0.0001), and IL-17 (P < 0.0001) were higher in TAO patients with amputation compared to controls. Conversely, the serum level of IL-10 was lower in this group (P < 0.0001).

Conclusion: Our results suggested that inflammatory cytokine production profile of T helper cells, can be significantly contributed in the progression of TAO disease.