The Role of Gut Microbiota in Breast Cancer Progression and Treatment: A Review
Kassa Y, Mulatie Z, Tilahun M, Shibabaw A, Tesfaye M, Eshetu B and Belete AG
Published on: 2024-04-26
Abstract
Breast cancer is the second most common cause of cancer deaths among. It is still a major cause of morbidity and mortality among women, despite all the available diagnostic and therapeutic options. Early diagnosis of breast cancer is one of the best approaches to preventing this disease. There is growing evidence demonstrating that the gut microbiota is involved in the pathogenesis of breast cancer, and fecal microbiota transplantation is considered to be a promising new therapeutic approach.
Bacterial communities within a host could be one additional environmental factor related to breast cancer that has only been recently considered in sporadic breast cancers of unknown etiology. Recently, efforts have been made towards fully characterizing the microbiota in different body parts under different health conditions, including breast cancer. The development of breast cancer is impacted by estrogen-dependent and non-estrogen-dependent functions of the gastrointestinal microbiome involving the production of bioactive metabolites. Intestinal microbiota dysbiosis has been linked to breast cancer because certain gut bacteria alter the production of beneficial anticancer metabolites and disrupt estrogen metabolism in the gut. In conclusion: Alterations of the gut microbiota play an important role in promoting the development of breast cancer. Therefore, careful attention to patients’ intestinal microecology should provide a sound basis for the diagnosis and treatment of breast.