GC-MS, FTIR Analyses and Antimicrobial Activities of Oily Fractions from the Ethyl Acetate Stembark Extract Pterocarpus Osun

Fadeyi AE, Akiode SO and Fenu M

Published on: 2024-02-24


Pterocarpus osun is has been used in traditional African medicine to treat various illnesses, particularly in the Southwestern zone of Nigeria. The viscous oily substance which was isolated from the ethyl acetate extract of stembark of P. osun was subjected to GCMS, FTIR and antimicrobial analyses to ascertain the chemical composition and its antibacterial activities respectively. The GCMS analyses of the oily fraction contain several chemical compounds with pharmacological functions such as antibacterial, antifungal, antioxidant, anticancer among others. Some of the prominent FTIR peaks shows alkane C-H stretch at 2921–2847cm-1 and 1454–1379cm-1; carboxylic acid C-O stretch at 1165–1032cm-1; carbonyl C=O stretch at about 1728–1709cm-1. This oily fraction demonstrated positive activity against the test organisms. The test organisms Escherichia coli, Salmonella typhi and Staphylococcus aureus are all susceptible to the samples with highest zones of inhibition recorded at highest concentration measured (10mg/mL). The recorded zones of inhibitions are comparable to that of the chloramphenicol employed as standard control for the test. Thus, the oily fractions isolated from the ethyl acetate extracts of the leaf and stembark of P. osun can be explored for novel therapeutic drug development.