Changes in Insulinogenic Index (IgI) for Glucose Tolerance Test (GTT) During Taking Imeglimin (Twymeeg)

Mori K, Bando H, Urasaki H, Kobayashi H and Nagahiro S

Published on: 2025-02-27

Abstract

Current case is 64-year-old male with type 2 diabetes (T2D), keeping HbA1c 5.6-5.8% for 2 years. Health check-up in June 2024 showed HbA1c 6.0%, GGT 54U/L, TG 214mg/dL, 68kg in weight. By 75gOGTT, insulinogenic index (IGI)-0-30min showed 0.074, with IGI-30-60min 0.192. For treatment, he started petite-low carbohydrate diet (LCD) and imeglimin (Twymeeg) 2000mg/day. Clinical improvement was observed for 4 months, with 6kg weight reduction, 6cm decreased abdominal circumference, HbA1c 5.9%, GGT 18U/L, TG 68mg/dL, IGI-0-30min 0.079, IGI-30-60min 0.987. Since imeglimin has effects of secreting insulin and decreasing resistance via mitochondria, it may improve glucose variability against GTT and impaired function.