Macrocytic Anemia Due to Excess Alcohol Consumption with Remarkable Improvement by Vitamin B12 Administration

Bando H, Yamashita H, Kato Y, Ogura K and Yada S

Published on: 2025-07-16

Abstract

The case was 56-year-old male with fatigue and pretibial edema. He continued excessive alcohol consumption for long and showed macrocytic anemia as Hb 8.6g/dL and mean corpuscular volume (MCV) 130fL (80-102). Blood concentration revealed lower Vitamin B₁₂ for 137pg/mL (180-914), normal range of folate 4.6ng/mL (4<) and Vitamin B₁ 37.0ng/mL (21.3-81.9). Pulse wave velocity (PWV) was negative for ABI 1.34/1.32 and baPWV 1413/1436 cm/sec. By ultrasound examination for lower extremities, blood flow was unremarkable from saphenous vein to femoral vein. Mecobalamin 1500 μg daily was provided for 4 months, and anemia was improved as Hb 14.3g/dL, and MCV 120fL.