Renal Cancer from Ukraine vs. Colombia and Spain

Jargin SV

Published on: 2026-03-30

Abstract

This is a commentary on the series of studies [1-7], in particular, the last one making a comparison of renal-cell carcinoma (RC) using tissue specimens from Ukraine with the control from Colombia and Spain [7]. The earlier research was commented previously [8]. RCs from Ukraine tended to be of higher grade than those from the control [1-7]. In the most recent study, the microvessel density in tumor tissue from patients residing both in “highly” and “low contaminated areas of Ukraine” [7] was higher than that in RC from Spain and Colombia (p<0.01). The difference between both Ukrainian groups was statistically insignificant. The increased angiogenesis was associated with a higher expression of the immunohistochemical marker VEGF (vascular endothelial growth factor) [7]. It was assumed that the exposure to ionizing radiation leads to an increase in the microvessel density, which in turn is associated with a higher grade and less favorable prognosis [6-9].