For recent decades, anti-aging medicine has been in focus. The authors and collaborators have continued various research concerning anti-aging medicine, aesthetic medicine, drug discovery medicine?Nicotinamide Mononucleotide (NMN), Macrophage-Activating Factor (MAF), and so on [1,2,3]. Furthermore, we have developed relational medical research for psychosomatic medicine associated with information and communication and technology [4,5]. Among them, novel achievement for human micro-vibration research has been reported which reflects a person's emotions and physiological state of the body [6].

From psychological point of view, a series of fundamental and clinical research were initiated for human vibration [7]. Extremely subtle or small micro-movements in the body can be captured using high-technique recording system. In particular, the movements in the face, eyes and head may reflect the emotional status and physiological situation, leading to the quantitative research. Such information can be obtained by the motion pictures in the face for about only 70 seconds [8]. Authors et al. have reported the gradual development of psychological research using micro-vibration so far [4,6]. In this report, the measurement method and related perspectives are described.

The relationship between micro-vibration and psychological status has been investigated by the measurement of VibraImage. The method involves a few stages where motion pictures can be analyzed by advanced technique (Figure 1). They are i) recording vibration parameters of the head in non-contact situation at rest, ii) measuring simultaneously brain waves and skin responses, iii) using big data from comparative experiments in psychological exams, and iv) flowing these process leading to the clarification of subject’s emotional states [9].

Figure 1: Measurement method of VibraImage.

a: Author Hoshi (left), Author Morizaki (right).

b: Keep relax and continue gazing for 60 seconds.

In this video recording, minute head and eye movements were recorded and then analyzed (Figure 2a). When a person moves their head, it is necessary to move their eyes in the opposite direction to obtain stable visual information. This reflex has been called the vestibulo-ocular reflex (VOR). The VOR is one of the important systems that supports spatial cognition and is found in many vertebrates. In other words, when the head rotates, the eyes rotate in the opposite direction around the eye axis (Figure 2b). This important reflex causes rapid compensatory eye movements in the opposite direction at the same speed as the head movement [10]. Therefore, high-speed foveal image stabilization allows us to move around and see clearly at the same time. If there was no VOR mechanism, we would see images recorded by a video camera with trembling hands.

Figure 2: The principle of vestibulo-ocular reflex (VOR).

a: Capturing micro-movement of eye, face and head.

b: Reverse movement of eye and head by VOR.

The current data obtained from the third author were analyzed and obtained several results. Characteristics of the results are as follows: i) The peak is shifted to the left: Fatigue situation would be present (Figure 3a), ii) The peaks are scattered over several areas: Unconscious issues are present and feelings are scattered within one minute, and iii) There is a lot of variation on the left side of the peak: It suggests mental fatigue [11]. Starting with an x position, vibes record shows the movement of feelings over one minute (Figure 3b). It starts from the anger zone (irritation, red) and moves to the comfort zone (green) where there is a high sense of elation. This seems to be a healthy tendency of moving feelings. The area means sad (blue) and joy (pink), respectively.

Figure 3: Obtained results of the analysis of charism analysis.

a: Frequency histogram showed wider peak with left shift.

b: Vibes record showed feeling movement for 1 minute.

These results shown here were only small part of the whole data from whole physical and psychological aspects in the subject. Current analysis named charism analysis can generally include several factors related to mental attractiveness. Mental attractiveness means the charming points of the person itself. Among them, fie factors have been pointed out to be shown for the mental attractiveness (Table 1).

Table 1: Factors for mental attractiveness.

1. Tokushima University: Recent research into nicotinamide mononucleotide and ageing. Nature 2022; 601.
2. Hoshi Y. Stella Medix Ltd.
3. Takara T, Takara R, Kobayashi A, Shirakata H, Ambai S, Shinohara Y, et al. Serum-Derived Macrophage-Activating Factor Exhibits Anti-Tumor Activity via M2-to-M1 Macrophage Reprogramming. Int J Transl Med. 2024; 4: 439-449.
4. Uto Y, Morizaki M, Bando H, Kasai Y, Bando M. Clinical Application of Micro-Movement of Head by Vibraimage for Psychological Traits Study. Asp Biomed Clin Case Rep. 2024; 7: 304-307.
5. Bando H, Uto Y and Morizaki M. Psychosomatic Evaluation by Previous Psychological and Novel Body Vibration Methods. Res J Sport Health Psychol. 2023; 5: 139.
6. Morizaki M, Uto Y, Bando H, Kasai Y and Bando M. Novel Psychosomatic Measurement by The Evaluation of Vibrathythm. Int J Case Rep Clin Image. 2024; 6: 227.
7. Money-Nolan LE, Flagge AG. Factors affecting variability in vestibulo-ocular reflex gain in the Video Head Impulse Test in individuals without vestibulopathy: A systematic review of literature. Front Neurol. 2023; 14: 1125951.
8. Castillo-Bustamante M, Pauna HF, da Costa Monsanto R, Gutierrez VA, Madrigal J. Insights Into Vestibulo-Ocular Reflex Artifacts: A Narrative Review of the Video Head Impulse Test (vHIT). Cureus. 2024; 16: e55982.
9. Rinaudo CN, Schubert MC, Figtree WVC, Todd CJ, Migliaccio AA. Human vestibulo-ocular reflex adaptation is frequency selective. J Neurophysiol. 2019; 122: 984-993.
10. Pham NC, Kim YG, Kim SJ, Kim CH. Effect of a differential training paradigm with varying frequencies and amplitudes on adaptation of vestibulo-ocular reflex in mice. Exp Brain Res. 2023; 241: 1299-1308.
11. Soriano-Reixach MM, Prieto-Matos C, Perez-Fernandez N, Rey-Martinez J. Effects of parameters of video head impulse testing on visually enhanced vestibulo-ocular reflex and vestibulo-ocular reflex suppression. Clin Neurophysiol. 2020; 131: 1839-1847.