Idiopathic Intracranial Hypertension (IIH) in a Patient on Tirzepatide: Cure or Culprit? A Case Report

Malagi AD, Modi K, Sonwane AC, Sethi BK and Modi KD

Published on: 2026-06-27

Abstract

Idiopathic intracranial hypertension (IIH) is a syndrome of elevated intracranial pressure commonly associated with obese females of reproductive age group. Incidence of IIH is approximately 0.9 in 100.00 and 3.5/100.00 in females of 15 to 44 years of age. Diagnosis is usually done by the modified Dandy criteria which includes signs and symptoms of raised ICP with absence of localizing findings on neurological examination, no evidence of deformity or obstruction of ventricular system and increased CSF pressure (> 250mm in adults and >280 mm in children), with neuroimaging signs of increased ICP and no other apparent secondary causes of intracranial hypertension present. The role of incretin based therapy in the management of IIH is emerging. We report a case of IIH observed during tirzepatide therapy raising discussion about its role in IIH.