Remarkable Reduction of HbA1c and Weight by Low Carbohydrate Diet (LCD) and Imeglimin (Twymeeg) in a Diabetic Male

Kawahito A, Sueki E, Aihara A, Ikezoe M, Fukushima N, Matsushima K and Bando H

Published on: 2026-01-12

Abstract

The patient is 59-year-old male with Type 2 diabetes (T2D) and obesity. He was pointed out to have T2D in July 2024 as HbA1c 7.2%. He started the treatment in October 2024, including low carbohydrate diet (LCD), imeglimin (Twymeeg), and empagliflozin as SGLT2-i. HbA1c and weight in 0, 6, 12 months were 8.0%, 6.1%, 5.8% and 82.6kg, 77.0kg, 72.1kg, respectively. Remarkable clinical efficacy was found, with no significant gastro-intestinal adverse effect (GI-AE). By pulse wave velocity (PWV), ankle-brachial index (ABI) showed 1.20/1.17 (right/left), with brachial-ankle pulse wave velocity (baPWV) 1783/1751, which suggests existing arteriosclerosis compared to the actual age.