The Association between Insulin Signaling, Type2 Diabetes, And Cognitive Dysfunction

Taguchi A

Published on: 2023-03-31

Abstract

Type 2 diabetes mellitus is a risk factor for dementia, including Alzheimer’s disease. This suggests the involvement of brain insulin signaling, mediated by insulin receptor substrate IRS proteins, in dementia. Reduced insulin signaling causes glucose intolerance and insulin resistance that progresses to type 2 diabetes and may negatively affect brain functions, whereas decreased insulin signaling improves neurodegenerative diseases, including Alzheimer’s disease. Understanding the diverse effects of reduced insulin signaling and impaired glucose metabolism on cognitive function and their molecular mechanisms may lead to the development of new treatments for these disorders.