Antifibrotic Effects of Triterpenoids Isolated from the Fruits of Euscaphis Fukienensis Hsu. in Mice

Odion Y, Tang Z, Li T, Huang A, Li U and Bem H

Published on: 2024-08-17

Abstract

Liver fibrosis (LF) is the major challenge to current human health. We do this research to document the effects of the triterpenoids from the fruits of Euscaphisfukienensis Hsu. (EFT) and the expression of TGF-β₁, PDGF, TNF-α and AngII in a murine model of LF. Sixty mice were equally divided into six study groups. Five groups were subcutaneous injected carbon tetrachloride (0.1 ml/10 g) for six weeks. Two of these five groups were treated with different concentrations of EFT (1.28 and 5.12 mg/10 g), one was treated with the water extracts of the triterpenoids from the fruits of Euscaphisfukienensis Hsu. (EFW) 6.39 mg/10 g, one with 0.1 mg/kg of Colchicine (positive control), and one with physiologic saline (negative control). After treating six mouth, mice were executed and then hepatic enzymes/function tests, hyaluronic acid and laminin levels were measured in serum, and hepatic histology, TGF-β₁, PDGF, TNF-α and AngII expression were documented in hepatic tissue. Our results show that both EFT and EFW could significantly attenuate the level of LF. The expression of TGF-β₁, PDGF, TNF-α and AngII mRNA and protein have different degrees of reduction in treated mice. Our researches clarify that triterpenoids are the material basis of the fruits of Euscaphis fukienensis Hsu. For the treating LF and preliminarily explain its mechanism.