The Rising Prevalence of Multiple Sclerosis: Influence of Oxidative Stress (Oxidative Stress and Multiple Sclerosis)

Wozniak G, Pashias G and Kyprou M

Published on: 2020-10-19

Abstract

Multiple Sclerosis (MS) is a neuro inflammatory possibly autoimmune in an etiology disease, with genetic and environmental risk factors. The major pathophysiological trait of the MS is the appearance of inflammatory demyelinating plagues. There is no genetic, experimental or pathological investigation that clearly suggests a single causative factor and thus a therapeutic target in MS. We searched for studies, reports, reviews, and editorials in the PubMed database, at least 5 years. The related articles were related to the risk factor’s influence in MS prevalence. The aim of this review was to give a better understanding of the risk factors manifestations, and their impact on MS prevalence and pathogenesis we discuss the potential biological mechanisms underlying the association between risk factors and MS. It is well established that the pathogenesis of MS involves the activation if immune system and inflammation plays a key role in the development of oxidative stress, resulting to the appearance of the pathological hallmarks of the disease. Obesity as inflammatory disorder, appears to be a major environmental factor contributing to the onset and progression of diseases and the principal lifestyle modifiable risk factor associated with an increased risk of developing type 2 diabetes.