An Evaluation of Analgesic and Anti-Inflammatory of Ethanolic Extract of Cynodon Dactylon on Stressed Rodent Model

Tahsin R, Noor F, Rupak AHB, Chowdhury Mc, Shurovi FS, Shurovi FS, Sarif S and Hasan M

Published on: 2022-01-30

Abstract

Cynodon dactylon is a perennial herb found in all tropical and subtropical areas, which is a well-known traditional medicine and possessed various pharmacological activities. The present work was aimed to explore the analgesic and anti-inflammatory activities of ethanolic extract of Cynodon dactylon on stressed rodent models. In this study, the anti-inflammatory activity of C. dactylon was determined using the carrageenan induced rat paw edema method, in which the inflammation was generated by intraperitoneal administration of a 1% Carrageenan (0.1 ml/100g) suspension, where ibuprofen was used as standard. After assessing the paw volume, it has been observed that the ethanolic extract of C. dactylon could significantly decrease the formation of edema induced by carrageenan. For the evaluation of both peripheral and central analgesic activity, the acetic acid writhing test as well as tail-flick method were utilized and aspirin was chosen as the reference standard. In the acetic acid writhing test, C. dactylon extract showed a significant reduction in pain against acetic acid-induced abdominal contractions produced by 1% acetic acid (10ml/kg). On the other hand, in the tail-flick method, the central analgesic effect of the C. dactylon extract against heat stress on their tails; was found to be significant at high doses (P<0.01) than low and medium doses. It can, therefore, be inferred that Cynodon dactylon could be utilized as a good alternative therapy in the treatment of inflammation and pain.