A Novel Nano-biodegradable polymers as a local drug delivery system for management of oral malignancy

Aboushelib M

Published on: 2022-06-25

Abstract

Chemotherapy represents one of the strategic management systems of cancer. Systemic side effects of chemotherapy may far exceed to suffering from the cancer itself. What if the drug is directly delivered as a single one dose inside the tumour itself so that active ingredients can directly target tumour cells? In our research oral squamous cell carcinoma, one of the most aggressive forms of cancer was chemically induced on mice. A triblock biodegradable polymer was synthesized in the form on nano-allow spheres which were loaded with a targeted anti-cancer drug and based on solubility, degradation, and release rates, the loaded vesicles were injected inside the tumour as a single long­term releasing dose. After two months the tumours were histologically evaluated to detect effect of injected drug. Results revealed significant improvement in the stage of cancer after treatment and some grade 3 tumours were reverted to carcinoma in-situ. All mice survived treatment and loading protocol. Release kinetics and drug tissue interaction will be illustrated. Hopefully this study could lead the way in targeted cancer therapy