Enumeration and Molecular Profiling Of Circulating Tumour Cells Can Minimize Radiotherapy Treatment for Management of Metastatic Cancer

Pravin D

Published on: 2022-06-25

Abstract

The new era of regenerative medicine, Dental Pulp Stem Cells (DPSCs) also have shown several applications in dental Medicine. It is mainly because, DPSCs can differentiate into various linage of cell types, easy to culture in vitro and easily availability of any discarded extracted teeth. Gronthos et.al 2000 and our study have shown that the stem cell properties of DPSCs are mostly similar with those of Bone Marrow Stromal Cells (BMSCs) or cord blood cells or any of the other adult stem cells extracted from various tissue & cells. Numerous studies including our work have clearly shown the DPSCs cells can differentiate into neuron, cardiomyocytes, adipose tissue cells, chondrocytes and beta cells secreting insulin granules. DPSCs also form dentin/pulp-like complexes when modulated with various growth factors such as Fibroblast Growth Factor (FGF), Transforming Growth Factor-β (TGF-β), Nerve Growth Factor (NGF), Platelet-Derived Growth Factor (PDGF), and Bone Morphogenic Proteins (BMPs) which help them to differentiate, proliferate and also helpful in wound healing process in various dental disorders. Several types of scaffolds are being used for use of these cells in dental medicine. The scaffolds mainly include collagen, hydrogel, decellularized bio scaffold, and Nano fibrous spongy microspheres etc. The combination of growth factors and scaffolds enhance the differentiation capacity of DPSCs to have dental-related cell types for rectifying dental defects. Our study have shown that DPSCs cells are belonging to Mesenchyme Stem Cells (MSCs) which can be used for the treatment of multiple diseases including dental disorders. Now it has been under investigation that Oral and maxillofacial defects can be treated by DPSCs cells in near future and this work is in great progress. This talk will mainly give an overview of development of DPSCs cells from dental pulp cells and their differentiation into various lineages of cell types with probable use of these cells in correcting dental defects caused by various factors.