Ascorbic Acid Supplementation Mitigate Sodium Benzoate Feed Additives Toxicity In Wister Rats

Aremu A, Adeyemi AO , Biobaku KT , Akorede GJ , Olatunji AO and Ambali SF

Published on: 2021-12-13

Abstract

The increases in the use of feed additives such as sodium benzoate as preservative, colorant and sweetener in modern food and beverage industries have become popular. There exist several deleterious adverse effects especially when combined with other additives thereby predisposing consumers to various health challenges such as cancer. This present study aimed at investigating the sub-chronic effects of sodium benzoate acid mitigated with ascorbic acid supplementation in Wistar rats The rats were divided into nine groups (of four rats each). Group one served as the negative control, while the other groups were paired and treated with graded doses of sodium benzoate (150, 200, 250, 300 mg/kg) and in the presence of ultraviolet activation. All exposed groups where treated with ascorbic acid at various doses. The result showed that all treated groups had no significant (P>0.05) effect on feed consumption pattern, morbidity, mortality, hematology and some serum biochemical parameters. The result further showed a significant (P <0.05) increase in serum ALT in the groups treated with sodium benzoate at a very high dose. The histopathology result showed degenerative and necrotic changes in both the kidney and the liver in the groups with higher doses of sodium benzoate exposure.