L-arginine Partially Ameliorated Some Biochemical and Oxidative Stress Parameters in Rats Exposed to Imidacloprid Toxicity
Akande MG, Adefioye AE, Fabowale OG, Akumka DD and Ejeh AS
Published on: 2024-06-24
Abstract
Imidacloprid is a neonicotinoid insecticide that is applied extensively for pest control, while L-arginine is an α-amino acid that is important in protein biosynthesis. The purpose of the research was to assess if L-arginine (AR) could improve biochemical and oxidative stress indices in rats exposed to imidacloprid (IM) toxicity. Forty (40) rats were randomly assigned to four groups. They received the treatments by oral gavage for 14 days: distilled water [DW group], imidacloprid (71 mg/kg) (IM group), imidacloprid (71 mg/kg) and L-arginine (100 mg/kg) [IM+AR100 group], imidacloprid (71 mg/kg) and L-arginine (200 mg/kg) [IM+AR200 group]. They were sacrificed after the study ended and the levels of serum proteins, serum enzymes, urea, creatinine and oxidative stress indices were estimated. Significant reductions were recorded in the total protein concentrations of the IM and IM+AR100 groups compared to that of the DW group respectively. Substantial declines occurred in the globulin levels of the IM and IM+AR100 groups relative to the DW and IM+AR200 groups respectively. The activities of hepatic catalase and renal superoxide dismutase of the IM group were significantly reduced relative to the IM+AR200 group respectively. Imidacloprid did not elicit marked toxicity in this investigation. However, L-arginine exerted partial ameliorative impacts on imidacloprid toxicity. Therefore, further research is needed for the exposition of the toxic mechanisms of imidacloprid and bioprotection by L-arginine.