Aged Female with Dementia, Zinc Deficiency and Type 2 Diabetes (T2D) Treated by Imeglimin (Twymeeg)

Bando H, Okada M, Ogawa T, Iwatsuki N and Sakamoto K

Published on: 2025-08-18

Abstract

Current patient is 85-year old female with type 2 diabetes (T2D), Alzheimer dementia (AD), and zinc deficiency. She was diagnosed with T2D for HbA1c 8.8% 4 years ago, and treated by metformin, alogliptin and imeglimin (Twymeeg), leading to stable situation with HbA1c 6.5%. She had dementia/mild cognitive impairment (MCI), and treated successfully by memantine and tiapride. Serum zinc concentration was 52 µg/dL (80-130 for normal range), and zinc acetate hydrate (Novelzin) 25mg/day was provided. The significant relationship among T2D, AD and zinc deficiency has attracted attention, in which AD would be Type 3 diabetes (T3D) for common pathophysiological background.