Diagnostic Relevance of Immunophenotyping in Leukemia

Gamde SM, Damisa N, Oladapo BD, Gracious BA and Daniel AA

Published on: 2025-07-17

Abstract

Leukemia has differential diagnoses. Eliminating disorders that could cause similar abnormalities in blood cell counts is crucial. Immunophenotyping is an important diagnostic approach in leukemia, allowing for the exact characterization of leukemia cells via surface antigen detection. Fluorochrome-conjugated antibodies target certain surface antigens determined by a cluster of differentiation counts are used to mark cell groups. This approach is critical in identifying leukemia sub-types, detecting minimum residual disease, and assessing therapy response. Hence, accurate immunophenotyping is critical for developing personalized treatment plans, adapting medicines to specific leukemia sub-types, and improving patient outcomes.