Acute HbA1c Reduction by Imeglimin (Twymeeg) in the Elderly Male with Benign Prostatic Hyperplasia (BPH)

Sueki E, Kawahito A, Aihara A, Ikezoe M, Fukushima N, Matsushima K and Bando H

Published on: 2026-01-22

Abstract

The patient is 72-year-old male with benign prostatic hyperplasia (BPH) by urologist. He was also treated type 2 diabetes (T2D) with unstable control, and introduced to our diabetes clinic. At the first contact, he showed HbA1c 7.9% and weight 58.3kg. Treatment started for low carbohydrate diet (LCD) and imeglimin (Twymeeg) followed by voglibose. Significant improvement was found for 3 months as HbA1c 7.0% and weight 54.8kg. Some perspectives and discussions include the relationship among T2D, LCD, imeglimin (Twymeeg), BPH with lower urinary tract symptoms (LUTS? and overactive bladder (OAB), naftopidil as an α1-adrenoceptor antagonist, and blood pressure control.