Anti-Müllerian Hormone (AMH) New Cutoff as a Possible Tool for the Diagnosis of Polycystic Ovary Syndrome (PCOS)

Al-Jefout M, Alnawaiseh C, Saleh M and Warwar K

Published on: 2021-02-20

Abstract

Objective: to find AMH cutoff value for PCOS diagnosis.

Methods: A total of 105 women: 85 with PCOS and 20 without PCOS. The cutoff value of the AMH level was evaluated using the receiver operating characteristic (ROC) analysis.

Results: AMH levels were significantly higher in PCOS women than controls (p < .001). AMH levels did not differ between PCOS phenotypes. ROC of AMH shows that participants with the cutoff of 23.97 pmol/L had the area under the curve of 0.844 (95% CI, 0.756–0.932), p-value <0.001 76.5% sensitivity, and 85% specificity for the presence or absence of PCOS. AMH in the PCOS group shows a gradual and steady decrease around the age of 50, while among controls, there was a sharp decrease at 35. Of all hormones, AMH correlated positively only with the Free androgen Index (p-value = 0.016). Lipid indices and AMH among PCOS participants did correlate, p-value >0.05.

Conclusions: The serum AMH level cutoff of 23.9 has good sensitivity and high specificity and maybe a new and useful diagnostic tool in PCOS diagnosis.