Obesity, Aging, and Diabetes May Bring Various Influence Including Immune Dysfunction

Bando H

Published on: 2024-12-23

Abstract

In developing medical research, immune dysfunction has been reported from not only autoimmune disease and communicable disease, but also diseases of obesity, aging and diabetes. Furthermore, inflammatory condition has been observed in these diseases. The presence of inflammation is thought to be the key component of immunosenescence, and it may become the leading direct consequence of aging. As related with aging process in the cell metabolism, autophagy has recently attracted attention. Autophagy plays the important role and regulates various immune responses. Obesity, aging, and diabetes share similarities in terms of decreased immune response and also increased chronic inflammation.