Onset of Type 2 Diabetes (T2D) in Female Case with Low BMI Treated by Imeglimin (Twymeeg)

Sakamoto K, Bando H, Iwatsuki N, Okada M and Ogawa T

Published on: 2026-04-03

Abstract

This patient is 76-year-old slender female of BMI 19.9 kg/m² with type 2 diabetes (T2D). She was previously treated for hypertension, dyslipidemia, and gastroesophageal reflux disease (GERD). In autumn 2024, she was diagnosed with T2D as HbA1c 10.1%. HbA1c decreased to 8.6% in 3 months by low carbohydrate diet (LCD) and Imeglimin (Twymeeg). By addition of empagliflozin from May 2024, HbA1c was 7.2% in December 2024 significant efficacy. Pulse wave velocity (PWV) showed almost standard range compared with the age. The relationship among T2D, sarcopenia, frailty, muscle volume and muscle power has been reported, in which several discussion was described.