Outcome of Photodynamic Therapy with Diode Laser and Indocyanine Green Modified Liposome against Animal Spontaneous Occurring Tumors

Okamoto Y, Yamashita M, Osaki T, Azuma K, Ito N, Murahata Y, Tsuka T, Imagawa T, Kaibori M, Suganami A and Tamura Y

Published on: 2022-01-21

Abstract

In 2010, we developed an ICG-modified liposome (ICG-lipo) in which indocyanine green (ICG) was bound to a phospholipid component. The treatment outcomes were evaluated for 38 cases of spontaneous tumors in animals. After intravenous administration of ICG-lipo (including anticancer drugs), the affected area was irradiated with light for 10-20 minutes using a semiconductor laser device. The irradiation interval was carried out from every day to 3 days in a week. The results based on the Response Evaluation Criteria in Solid Tumors (RECIST) were as follows: Complete Response (CR): 3 cases, Partial Response (PR): 13 cases, Stable Disease (SD): 18 cases, and Progressive Disease (PD): 4 cases. The response (CR and PR ratio) and efficacy rates (CR, PR, and SD ratio) were 42.1% and 89.5%, respectively. In particular, the response rate for lymphoma was high at 85.7%. In more than two cases of tumors, the efficacy rate was 100% except for lymphoma and hemangiosarcoma. Approximately half of the veterinarians reported improvement in the general condition after treatment. This demonstrates the effectiveness of this therapy.