Parallel Change Tendency of HbA1c and LDL-C in Diabetic Patient Treated by Imeglimin (Twymeeg)

Bando H, Okada M, Ogawa T, Iwatsuki N and Sakamoto K

Published on: 2026-03-05

Abstract

Current patient is 46-year-old male of BMI 26.9 kg/m² with type 2 diabetes (T2D) and dyslipidemia. Family history was positive as younger sister was T2D. Pulse wave velocity (PWV) showed normal ranges of ankle brachial index (ABI) and Cardio-Ankle Vascular Index (CAVI). He has been treated with low carbohydrate diet (LCD) and imeglimin (Twymeeg) for 4 years. In former 2 years, his diabetic control was satisfactory as HbA1c 5.9% and LDL-C 142mg/dL, but HbA1c and LDL-C increased to 8% and 172 mg/dL in last 2 years associated with parallel relationship. He tolerated imeglimin well without gastro-intestinal adverse effects (GI-AE).