Linking Cancer Mortality to Clinical Staging, Grading and Therapeutic Modalities, Over One Decade, Oncology Unit, Dubai Hospital, Dubai UAE 2019
Nezar Ahmed Salima, Hussain H, Raja Kathamuthu, Mohammed Tuffaha and Amna Al Mehairi
Published on: 2018-12-28
Background: Improving cancer survival is a key challenge identified in ‘improving outcomes: a strategy for cancer, and stage at diagnosis is highly predictive of cancer mortality, and a possible explanation for the difference in cancer survival.
Objectives: To study the association between cancer mortality and clinical staging of the cancer cases, grading of the cancer cases, and clinical therapeutic protocols applied for cancer cases throughout 10 years of cancer admissions at oncology center, Dubai hospital, and Dubai health authority.
Methodology: Hospital based registry data we obtained retrospectively through oncology department registry Unit in Dubai Hospital for the period 2006 -2016, all admitted cases were included in the data analysis, they were male and females, all age groups and all nationalities. Data coding, data entry and data analysis were made utilizing SPSS 21 software, ethical standards were followed, and diagnosed and confirmed cases by Histopathology studies were considered only
Results: The current study showed that mortality rate of cancer patients admitted to oncology center at Dubai Hospital in 2005 12.9/1000, 14.4/1000 in 2006. 16.14/1000 in 2008, in 2009-2012 decline down and raise once again 2013 to 16.89/1000, after 2013 the mortality rate decline down to 7.24/1000, clinical staging has significant statistical association with cancer outcomes, as stage 5 cancer cases showed death about (33%) of the cancer cases), stage 4 cancer cases showed 12.9% death, stage 3 showed 6.4% death of total cancer cases and stage 1 and 2 revealed the least death 2.8%, P vale <0.05. Present study revealed significant association between cancer grading and cancer outcome as in grade 4 cancer showed highest death rate (18.7%) followed by grade 3 about( 15.7%, ), grade 2 (11.2%) and grade one about( 6.6%) P value showed <0.05. This study reflects significant statistical association between therapeutic protocol and the cancer outcome, the least death rate where shown among hormonal therapy 11.1% and adjuvant therapy (11.2%) and surgical therapy 11% while chemotherapy showed 21.8% death among all cancer cases. P value was <0.05.
Conclusion: The study concluded that cancer mortality has tactical significant association with clinical staging of cancer at time of diagnosis, cancer cases grading, therapeutic modalities applied and management protocol as well as well as gender.