Outcome Analysis of Colorectal Cancer by Location

Chandio A, Chandio M, Shaikh Z, Memon N, Memon A and Brown K

Published on: 2022-09-02

Abstract

Colon cancer exhibits differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumour. Though clinical management of colon cancer usually has not accounted for the primary tumour site, left-sided and right-sided colon cancers harbor different clinical and biologic characteristics.

Aim: To investigate the incidence trend of colorectal cancer and analyzed its characteristics by gender, age, site and other aspects

Methods: All patients managed with colorectal cancer from January 2015 through December 2019 were retrospectively identified from the referral database created by the colorectal specialist nurses in the colorectal service.

Inclusion: All patients diagnosed with colorectal cancer.

Exclusion: Tumour in the Appendix, Anal canal, small bowel, metastatic tumours of unknown primary.

Results: 976 patients were diagnosed with bowel cancer percentages of studied participant were Male 52.60% and Female 47.40%. The mean age of 74.14 years. Sixty six (66) 6.76% patients were excluded from the study. Annual incidence rate of colorectal cancer remains almost steady. The location of colon cancer is also changing, the incidence rate of Right side colon cancer in women was much higher than that in men, and on Left side colon cancer including rectum was much higher in men than that in women this was especially exhibited in cases of rectal cancer. In the Age group 20-49 years incidence of colorectal cancer was 5.38% in the 50 –79 years group, the incidence remained the highest 65.05% while Age group 80-99 year’s incidence 28.90% and over age group 100 years 0.65%. Surgical intervention was performed in 69.89%, Supportive care palliatively was given to 24.50% patients. In the Right colon subset of patients there was a total of 37.58% patients In Left Colon cancer 33.29% patients and rectal cancer 29.12% patients. 32.08 % patients died during the study period. Incidence of colorectal cancer was greater for cancers of the left side of colon than right colon (62.41% vs 37.58%).

Conclusion: Left sided colon cancers have a worse prognosis than Right sided colon cancers. Establishment of comprehensible management for location of colon cancer is needed.