Relationships Between Iodine and Some Chemical Elements in Normal Thyroid of Females Investigated by Short Neutron Activation

Zaichick V

Published on: 2023-01-26

Abstract

Thyroid diseases rank second among endocrine disorders, and prevalence of the diseases is higher in the elderly as compared to the younger population. An excess or deficiency of chemical element contents in thyroid play important role in goitro- and carcinogenesis of gland.   The correlations with age of the eight-chemical element (ChE) contents (Br, Ca, Cl, I, K, Mg, Mn, and Na), I/Br, I/Ca, I/Cl, I/K, I/Mg, I/Mn, and I/Na content ratios, and inter relationships between ChE contents and I/ChE content ratios in normal thyroid of 33 females (age range 3.5-87 years) was investigated by instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Our data reveal that the Ca content, as well as I/Mg and I/Mn content ratios increase, while Cl content and I/Br content ratio decrease in the normal thyroid of female during a lifespan. Therefore, a goitrogenic and tumorogenic effect of excessive Ca level in the thyroid of old females and of disturbance in intrathyroidal I/Mg and I/Mn relationships with increasing age may be assumed. Furthermore, it was found that the levels of Br, Ca, Cl, K, Mg, Mn, and Na in the thyroid gland are interconnected and depend on the content of I in it. Because I plays a decisive role in the function of the thyroid gland, the data obtained allow us to conclude that, along with I, such ChE as Br, Ca, Cl, K, Mg, Mn, and Na, if not directly, then indirectly, are involved in the process of thyroid hormone synthesis.