Association of Periprocedural Haemoglobin Reduction and Myocardial Injury in Patients with Unstable Angina Undergoing Percutaneous Coronary Intervention

Bagchi SK, Moniruzzaman MD, Nahar S, zzaman K, Chowdhury S and Choudhury AK

Published on: 2023-10-04

Abstract

Background:

Patients undergoing percutaneous coronary intervention are at risk of different complications such as periprocedural bleeding and haemoglobin reduction that can lead to myocardial injury. Blood loss through catheter during procedure and through puncture site haematoma causes periprocedural haemoglobin drop.

Objectives:

To find out the association of haemoglobin reduction and myocardial injury after PCI in patients with unstable angina.

Methods:

This prospective observational study was conducted at National Institute of Cardiovascular Diseases (NICVD) for one year of time. Total 130 patients were enrolled based on inclusion and exclusion criteria during the study period. Haemoglobin and troponin-I were measured before and after PCI within 24 to 48 hours of the procedure. On the basis of post procedural haemoglobin level the study population were categorized into two groups: Group I patients with normal haemoglobin level and Group II patients with significant haemoglobin reduction (≥1 gm/dl).

Results:

Total 24 patients developed periprocedural myocardial injury, among them 17 (70.8 %) were in reduced haemoglobin group and 7(29.2%) in normal haemoglobin group. Elevation of troponin I after PCI had higher in group II than group I patients with statistically significant difference. Multivariate logistic regression analysis showed that haemoglobin reduction was an independent predictor of PMI (OR 1.94; 95% CI, 1.241-8.684; p=0.01). There was negative correlation found between periprocedural haemoglobin reduction and myocardial injury (r= --0.36, p= 0.01) by Pearson’s correlation coefficient test.

Conclusion:

Periprocedural haemoglobin reduction in patients of unstable angina was associated with myocardial injury after percutaneous coronary intervention (PCI).