Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Lead to Depolarization of Vagus for Occurrence of Congestive Heart Failure for Cause Sudden Cardiac Arrest during PTCA Procedure

Sharma PK

Published on: 2023-10-17

Abstract

Object:

Coronary artery disease is by atherosclerosis a disease state of heart which act as the base of other disease of heart. So my research work is to dissolve this plaque more efficiently with less side effect and more effectively .Sudden cardiac arrest (SCA) is a condition in which the heart suddenly and unexpectedly stops beating. If this happens, blood stops flowing to the brain and other vital organs. SCA usually causes death if it's not treated within minutes.

Method:

This plaque is majorly formed by cholesterol (LDL) so to dissolve this first we need to decrease the formation this LDL so there is composition of chemical which lead to decrease or stop the formation of LDL in liver after the mevolanate formation as we all know mevalonate is important for us. All receptor will accept this composition first it decrease the formation of VLDL and then it start removing the plaque which is already present in the artery wall. It can be given to a patient also who are at the border of having atherosclerosis. also given to a patient who are having sedentary life style .There is a composition of two elements which lead to decrease the chance of sudden cardiac arrest because .Majorly is seen that if the delivery of baby is not normal or pre mature delivery can lead to cause of cardiac arrest. However it doesn’t mean that normal delivery person do not develop the cardiac arrest but the percentage is low as compare to these person whose delivery is not normal .the major cause of sudden cause of sudden cardiac arrest that during first month of pregnancy if mother develop hypertension above 150/85mm of hg.

Observation and Result:

This prospective observational study was conducted at National Institute of Cardiovascular Diseases (NICVD) for one year of time. Total 130 patients were enrolled based on inclusion and exclusion criteria during the study period. Haemoglobin and troponin-I were measured before and after PCI within 24 to 48 hours of the procedure. On the basis of post procedural haemoglobin level the study population were categorized into two groups: Group I patients with normal haemoglobin level and Group II patients with significant haemoglobin reduction (≥1 gm/dl). The plaque is dissolved with very less side effect like urine colour will change into yellow if given then prescribed dose constipation can occur . Dizziness may occur if dose interval is not maintain. Cannot given to a patient suffering from asthma and liver cirrhosis if given in prescribed amount then it will reduce plaque as it is a good lipid lowering agent as it is better than beta blocker and calcium channel blocker and increase synthesis of HDL.

Results:

Total 24 patients developed periprocedural myocardial injury, among them 17 (70.8 %) were in reduced haemoglobin group and 7(29.2%) in normal haemoglobin group. Elevation of troponin I after PCI had higher in group II than group I patients with statistically significant difference. Multivariate logistic regression analysis showed that haemoglobin reduction was an independent predictor of PMI (OR 1.94; 95% CI, 1.241-8.684; p=0.01). There was negative correlation found between periprocedural haemoglobin reduction and myocardial injury (r= --0.36, p= 0.01) by Pearson’s correlation coefficient.