Journal of Clinical Gastroenterology and Hepatology Research is a peer-reviewed, open-access journal dedicated to the basic, clinical and translational studies of the physiology of the Digestive System, Gastrointestinal disorders and diseases of related organs. The Journal aims to provide a platform for the exchange of scientific information addressing clinical research and practice of Gastroenterology and Hepatology.
JCGHR publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas.
This peer-reviewed journal includes original articles as well as scholarly reviews, with the goal that all articles published will be immediately relevant to the practice of the specialties of gastroenterology and hepatology. All submitted papers are reviewed by at least two referees experts in the field of the submitted paper.
MISSION: The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide, seeks to publish papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology.
Title: Journal of Clinical Gastroenterology and Hepatology
Abbreviation:J Clin Gastro Hepatol Res
Publication Type: Journal
Aim and Scope
The main aim of the journal is to provide further understanding and insight into disease mechanisms and new therapies related to gastroenterology and hepatology. Topics of interest include but are not limited to the following: Gastroenterology- Endoscopy- Inflammatory bowel disease- Pancreatic disease- Celiac disease- Gastrointestinal motility- Hepatology- Hepatocellular carcinoma- Chronic hepatitis- Viral hepatitis- Cirrhosis- Liver disease- Partial Hepatectomy- Schistosomiasis- Appendicitis- Peritonitis- Colon Polyps- Constipation.
We encourage researchers, and other clinical and health professionals Worldwide to submit their manuscripts describing their original basic or clinical research findings and new diagnostic techniques to the Journal of Clinical Gastroenterology and Hepatology Research.
Gastroenterology is the branch of medicine which deals with the study of digestive system and diseases of the related organs. It involves detailed understanding of the physiology and functioning of the gastrointestinal organs. Diseases affecting gastrointestinal tract are the major focus of Gastroenterology. Hepatology is the study of liver, pancreas and biliary tract are considered as sub-specialty in this study.
Digestive system or Alimentary system:
The digestive system or alimentary system consists of accessory organs of digestion from mouth to anus along the alimentary canal and gastrointestinal tract. Digestive organs include esophagus, stomach, small intestine, colon and rectum, pancreas, gallbladder, bile ducts and liver. Digestive systems’ main function is digestion and absorption of food. The gastrointestinal tract is responsible for mechanical breakdown of food into small molecules that starts in mouth and continues into stomach and chemical digestion by enzymes helps to absorb the nutrients into the body which continues in the intestines.
Hepatology is the sub specialty in Gastroenterology which deals with the study, analysis, prevention and administration of ailments that influence Liver. Liver is the vital organ which plays a major role in metabolism. Liver is highly specialized and regulates a wide range of high volume biochemical reactions. Liver weighs about 1.44-1.66 kgs located at upper right quadrant of abdominal cavity and rests below diaphragm to the right of the stomach and overlies the gallbladder.
Liver diseases are also termed as hepatic disease. Most commonly found liver disease includes Hepatitis, Jaundice, Cirrhosis, Alcoholic Liver Disease, Non-Alcoholic Fatty Liver and Liver Abscesses. Liver disease rarely results in pain, portal hypertension and immunosuppression.
The esophagus also known as gullet which consists of muscular tube through which the food passes to stomach. The average length is 25 cm and varies with height. High amounts of food is passed over time in the esophagus and so it protected by a mucous membrane of epithelium and acts as a smooth surface.
Esophageal disorders are often associated with swallowing disorders where prolonged swallowing time is observed. Other disorders of Esophagus include Gastroesophageal Reflux normally called as Heartburn, Barrett’s Esophagus, Esophageal Cancer, Esophageal Motility Disorder and Esophageal Dysphagia which can prevent the food passage leading to difficulty in swallowing and can completely block the esophagus.
Stomach is a vital organ of the body which plays an important role in digestion. The stomach is a J shaped organ but it varies in size and connected to esophagus to its upper end and small intestine at its lower end. Gastric juice produced by the stomach plays an important role in digestion. To protect the stomach from the acid, mucus is produced which acts as a protective layer. Diseases of stomach are often caused by the infection of Helicobacter pylori such as Ulcers, Stomach Cancer and Gastritis.
The lower gastrointestinal tract consists of the small intestine and large intestine. It starts with the sphincter of the stomach and ends at the anus. The cecum imparts the small and large intestine. Most of the food digestion takes part in small intestine and in the large intestine the water is absorbed and the remaining waste is stored as feces before defecation.
Generally, inflammation of the intestines is found which leads to several disease conditions such as Enterocolitis, Inflammatory Bowel Disease and Intestinal Ischaemia.
Rectal and Anal diseases:
The rectum is the final straight portion of the large intestine and is followed by the anal canal. The rectum acts as a temporary storage site for feces. The anal canal is the terminal part of the large intestine. In humans, it is approximately 2.5 to 4 cm long.
Rectal and Anal diseases may be asymptomatic or may present with pain, a feeling of incomplete emptying or pencil-thin stool and these diseases are commonly seen in elderly people.
The pancreas is a glandular organ in the digestive system. It is located in the abdominal cavity behind the stomach and produces many hormones as it is an endocrine gland. The pancreas secretes fluid that has enzymes, into the duodenum which helps in the breakdown of carbohydrates, proteins and lipids.
There are a variety of disorders of the pancreas including Pancreatitis due to inflammation of the pancreas, Hereditary Pancreatitis and Pancreatic cancer. Pancreatic diseases result in abdominal pain, vomiting and nausea.
The biliary system refers to the liver, biliary tract and gall bladder. Bile is secreted by the liver into small ducts that join to form a common hepatic duct. The secreted bile is stored in the gall bladder which is a small organ where the stored bile is concentrated before it is released it into the small intestine. Bile helps in the absorption of vitamin k from the diet. The hepatobiliary system affects the biliary tract to secrete bile in order to aid the digestion of fats.
Diseases of the biliary tract (gallbladder and bile ducts) are common and result in significant morbidity and mortality. Diseases such as Cholangitis and Cholecystitis are due to inflammation of bile duct and gall bladder respectively.
To undergo diagnosis for digestive disorders patient has to undergo an extensive diagnostic evaluation prior to which thorough and accurate medical history is taken and on studying the symptoms the affected individual may have to give lab tests and imaging tests.
Fecal Occult Blood Test:
A fecal occult blood test looks for the hidden blood in the stool. A small amount of stool is placed on the card and checked.
A small sample of stool is collected and checked for the presence of abnormal bacteria in the digestive tract which may cause diarrhea.
Renal Function Test: Patients with reduced kidney function or renal failure undergo kidney function tests prior to imaging tests. These tests include blood creatinine test and creatinine clearance tests, blood urea test, urinalysis, urea clearance test and eGFR (estimated glomerular filtration rate).
Barium Meal Test: The patient eats a meal containing barium his allows the radiologist to watch the stomach as it digests the meal. The amount of time it takes for the barium meal to be digested and leave the stomach gives the healthcare provider an idea of how well the stomach is working and helps to find emptying problems that may not show up on the liquid barium X-ray.
Colorectal Transit Study:
This test shows how well food moves through the colon. The patient swallows capsules containing small markers which are visible on X-ray. The patient follows a high-fiber diet during the course of the test. The movement of the markers through the colon is monitored with abdominal X-rays taken several times 3 to 7 days after the capsule is swallowed.
Computed Tomography Scan (CT or CAT Scan): This is an imaging test that uses X-ray and a computer to make detailed images of the bones, muscles, fat and organs.
Defecography is an X-ray of the anorectal area that evaluates completeness of stool elimination, identifies anorectal abnormalities, and evaluates rectal muscle contractions and relaxation. The patient's rectum is filled with a soft paste that is the same consistency as stool. The patient then sits on a toilet positioned inside an X-ray machine and squeezes and relaxes the anus to expel the solution. The radiologist studies the X-rays to determine if anorectal problems happened while the patient was emptying the paste from the rectum.
Magnetic Resonance Imaging (MRI):
MRI is a diagnostic test that uses a combination of large magnets, radiofrequencies, and a computer to produce detailed images of organs and structures within the body. The patient lies on a bed that moves into the cylindrical MRI machine. The machine takes a series of pictures inside of the body using a magnetic field and radio waves. The computer enhances the pictures produced.
Ultrasound is a diagnostic imaging technique that uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs. Ultrasounds are used to view internal organs as they function, and to assess blood flow through various vessels. Gel is applied to the area of the body being studied, such as the abdomen, and a wand called a transducer is placed on the skin. The transducer sends sound waves into the body that bounce off organs and return to the ultrasound machine, producing an image on the monitor.
Colonoscopy: Colonoscopy helps to view the entire length of the large intestine (colon). It can often help identify abnormal growths, inflamed tissue, ulcers, and bleeding. It involves inserting a colonoscopy, a long, flexible, lighted tube, into the rectum up into the colon.
ERCP is a procedure that allows diagnosing and treating problems in the liver, gallbladder, bile ducts, and pancreas. The procedure combines X-ray and the use of an endoscope. This is a long, flexible, lighted tube. The scope is guided through the patient's mouth and throat, then through the esophagus, stomach, and duodenum (the first part of the small intestine). The healthcare provider can examine the inside of these organs and detect any abnormalities. A tube is then passed through the scope, and a dye is injected that will allow the internal organs to appear on an X-ray.
Capsule endoscopy helps to examine the small intestine. This procedure is helpful in identifying causes of bleeding, detecting polyps, inflammatory bowel disease, ulcers, and tumors of the small intestine. A sensor device is placed on a patient's abdomen and a PillCam is swallowed. The PillCam passes naturally through the digestive tract while transmitting video images to a data recorder. The data recorder is secured to a patient's waist by a belt for 8 hours. Images of the small bowel are downloaded onto a computer from the data recorder.
Esophageal pH Monitoring
An esophageal pH monitor measures the acidity inside of the esophagus. It is helpful in evaluating gastroesophageal reflux disease (GERD). A thin, plastic tube is placed into a nostril, guided down the throat, and then into the esophagus. The tube stops just above the lower esophageal sphincter. This is at the connection between the esophagus and the stomach. At the end of the tube inside the esophagus is a sensor that measures pH, or acidity. The other end of the tube outside the body is connected to a monitor that records the pH levels for a 24 to 48 hour period. Normal activity is encouraged during the study, and a diary is kept of symptoms experienced, or activity that might be suspicious for reflux, such as gagging or coughing, and any food intake by the patient. It is also recommended to keep a record of the time, type, and amount of food eaten. The pH readings are evaluated and compared to the patient's activity for that time period.
Gastrointestinal radiation oncology
Gastrointestinal interventional therapy
Gastrointestinal infectious diseases
Gastrointestinal laboratory medicine
Inflammatory bowel disease
Liver disease and transplantation
Colon cancer surveillance
Minimal hepatic encephalopathy
Hepatitis and other liver diseases
Instructions for Authors
Instructions for Authors
Before submission of manuscript to the journal, kindly check the below mentioned guidelines
All persons who qualify for authorship should be listed as authors. However, the corresponding author must ensure that each author listed has substantially contributed or participated sufficiently in the work and is responsible for that particular portion of the manuscript. However, people who do not qualify for authorship should be listed in acknowledgments.
First name and last name
Complete affiliation, along with the country
E-mail address (mandatory for the corresponding author)
Submissions to Pubtexto journals should include the following:
Figures and Tables
Authors are encouraged to submit all the components as \\\'zip file\\\' while submitting on our online system or via email as an attachment.
Cover Letter should:
briefly summarize or provide an outline of your manuscript, and why it is a worthy contribution to the concerned journal;
specify the Pubtexto journal that your manuscript best pertains to;
indicate, if applicable, that it is submitted as a part of Special Issue;
Specify the manuscript type (original research, review, etc.)
detail any previous interaction(s) with Pubtexto Publications (previously submitted)
specify all authors information, including affiliation
include acknowledgments and funding information (if applicable) and any competing interests
The word count for original research is 3500–4000 words and up to 5500 words for studies involving meta-analysis. Authors are encouraged to employ a standard and concise writing style. If you are not a native English speaker, we encourage you to utilize our language editing services-or ask a native English speaking colleague for assistance.
Title: The title should not exceed 200 characters and set in title case. The title should be concise, specific, and easily comprehensible to readers.
Abstract: The abstract should not exceed 300 words and may or may not be unstructured (without sub-heading such as objective, methodology, results, discussion, etc.). It should provide a clear description of the objective(s) of the study, demonstrate the methodology used, and summarize the study\\\'s prime conclusion(s). In the end, a statement regarding the study\\\'s significance to a potentially wider audience should be included.
Keywords: Authors can provide 4-6 keywords. The first letter of each keyword should be upper case, and keywords should be separated by a semicolon (;)
The introduction should set the tone of the paper by providing a clear statement of the study, the relevant literature on the study subject and the proposed approach or solution. The introduction should be general enough to attract a reader's attention from a broad range of scientific disciplines.
Materials and methods
This section should provide a complete overview of the design of the study. Detailed descriptions of materials or participants, comparisons, interventions, and types of analysis should be mentioned. However, only new procedures should be described in detail; previously published procedures should be cited and important modifications of published procedures should be mentioned briefly. Capitalize trade names and include the manufacturer\\\'s name and address.
Results and Discussion
The results section should provide complete details of the experiment that are required to support the conclusion of the study. The results should be written in the past tense when describing findings in the authors experiments. Previously published findings should be written in the present tense. Results and discussion may be combined or in a separate section. Speculation and detailed interpretation of data should not be included in the results but should be put into the discussion section.
This section should provide to adhere to support the study conclusions. This section included briefly detailed conclusive parameters of the whole study.
This should include all the people who have contributed toward the work in one way or the other. However, authors are required to ensure that people acknowledged should agree to be so named.
List all the sources of funding, including relevant research grant numbers, as applicable. Also, authors are encouraged to list all the contributing authors associated with specific funding, if applicable.
While we are not obligated to use these or recommend to the concerned Editor(s), we do encourage authors to provide names and contact information of 2-4 external reviewers and, if applicable, 1-2 opposed reviewers.
Published work along with any citable items should be cited in the reference list. While we follow very stringent reference formats, authors need not to spend time formatting their reference. They can submit the manuscripts formatted in any reference style (style will be formatted once the manuscript is accepted for publication), but it is preferable that they adhere to the journal format.
Pubtexto uses the following style. Items are listed numerically in the order they are cited in the text.
Example journal article (2-6 authors): Salwachter AR, Freischlag JA, Sawyer RG, Sanfey HA, Fukushima H, Cureoglu. The training needs and priorities of male and female surgeons and their trainees. J Am Coll Surg. 2005; 201: 199-205.
Example journal article (more than 6 authors): Fukushima H, Cureoglu S, Schachern P, et al. Cochlear changes in patients with type 1 diabetes mellitus. Otolaryngol Head Neck Surg. 2005; 133: 100-6.
Example book: Modlin J, Jenkins P. Decision Analysis in Planning for a Polio Outbreak in the United States. San Francisco, CA: Pediatric Academic Societies; 2004.
Example book chapter: Solensky R. Drug allergy: desensitization and treatment of reactions to antibiotics and aspirin. In: Lockey P, ed. Allergens and Allergen Immunotherapy. 3rd ed. New York, NY: Marcel Dekker; 2004:585-606.
Example online article: Wolf W. State\\\\\\\'s mail-order drug plan launched. Minneapolis Star Tribune. May 14, 2004:1B
Example article from any database: Calhoun D, Trimarco T, Meek R, Locasto D. Distinguishing diabetes: Differentiate between type 1 & type 2 DM. JEMS [serial online]. November 2011; 36(11):32-48. Available from: CINAHL Plus with Full Text, Ipswich, MA. Accessed February 2, 2012.
In-text citation: For referencing an article, a number is used. This is different from in-text citations in AMA—author\\\\\\\'s last name is not used. The order of numbering will be contingent on the order in which you use that reference within your paper. For example, the first article referenced will be given number one in superscript (1) followed by the second and third articles as 2,3. In the references section, the articles should appear numerically in the order they are cited within the text.
Figures and Tables
Figures and tables should be included in the main text (manuscript) to aid in the review process. However, for larger files (size exceeding 10 Mb) must always be submitted separately (should be properly mentioned in the main text, wherever applicable).
Figure captions and legends
Figure files should be included in the main document, and not as supplemental materials. Figure caption should be preceded by the figure, while figure legends should immediately follow the figure. Figure captions should be concise (not to exceed 18 words) and set in bold type. All figures should be numbered in sequence, using Arabic numerals, for example, Figure 1, Figure 2, etc.
Table captions and legends
Tables should be cited in ascending numeric order. Each table should be preceded by a table caption (brief and specific; not to exceed 18 words), and immediately followed by table legends, if applicable, used to explain abbreviations and other supporting information about the data. Larger tables, however, can be submitted as supplemental materials.
Review Comments and Revision
While submitting a revised manuscript, the authors should include the following:
Revised manuscript (clean copy): Prepare a clean copy of your revised manuscript that does not show track changes. Rename this file as \\\"Main Document\\\".
Revised manuscript (marked-up copy): Include a copy of your manuscript file showing the changes you have made (track changes). Rename this file as \\\"Manuscript with Track Changes\\\".
Response to reviewers: Address the specific points made by each Reviewer and/or Editor. Include your responses to all the reviewers\\\\\\\' and editor\\\\\\\'s comments and list the changes you have made to the manuscript. Rename this file as \\\"Response to Reviewers\\\".
Information integral to the comprehensive understanding of the manuscript, but is either too large to be included in the main document or due to any other reason, should be submitted as support materials, such as 3-D visualizations, interactive graphics, large tables and/or figures, and so on. However, authors should note that normal figures and tables should not be included under supplemental materials.
For manuscripts reporting medical studies that involve human or animal subjects, the ethics committee that approved the study must be identified in the manuscript. For studies involving human subjects, all work must conform to the recognized standards as per the \\\"Declaration of Helsinki\\\". In case of any experiments involving animals, authors must provide a declaration that all measures were taken to avoid animal suffering at each stage and also must furnish a detailed description of the procedures used.
In manuscripts reporting patient cases, patient anonymity must be preserved. Case reports submitted to Pubtexto Publications should conform to the International Committee of Medical Journal Editors\\\' recommendations. Patient privacy should be taken care of, and personally, identifiable information should not be revealed without informed consent. If informed consent has been obtained, the details must be mentioned in the manuscript.
For live patients, signed consent is mandatory if the authors wish to reveal the patient\\\\\\\'s identity. In the case of deceased patients, consent must be taken from the patient\\\\\\\'s next of kin. If a patient\\\\\\\'s consent was not obtained, the patient\\\'s details should be anonymized as much as possible. Patient\\\\\\\'s photographs need to be cropped sufficiently to prevent the revelation of identity.
Authors are not required to submit a copy of the patient\\\'s consent while submitting their manuscript for consideration in Pubtexto Publications. However, they should confirm in the Cover Letter that the patient\\\\\\\'s consent has been obtained. In certain instances, the Editorial Office might request the authors to provide a copy of the same.