Ferroptosis And Liver Diseases

Shize X and Wei L

Published on: 2023-08-09

Abstract

Ferroptosis is a kind of iron-dependent regulatory cell death, which is different from apoptosis, autophagy and necroptosis in morphology and biochemistry. Morphologically, it is mainly characterized by atrophy of mitochondria, increase of membrane density, rupture of outer membrane, reduction or disappearance of cristae, normal size of nucleus and no chromatin condensation. The biochemical characteristics were mainly abnormal accumulation of iron and ROS and decreased GPx4 enzyme activity. Many studies have shown that Ferroptosis is involved in the occurrence and development of many liver diseases, which suggests that regulating Ferroptosis may be a new way to treat such liver diseases. Therefore, this paper summarizes the research progress of Ferroptosis and its application in liver diseases, hoping to provide a new theoretical basis for the treatment of liver diseases.