Nodular Lymphoid Hyperplasia: An Asymptomatic Case Report

Alvarez-Garcia M, Otegui L and Bosch O

Published on: 2025-07-17

Abstract

Nodular lymphoid hyperplasia (NLH) is a condition with unknown etiology characterized by the presence of numerous mucosal nodules between 2 and 10 millimeters in diameter distributed mainly in the small intestine [1]. Some patients have an associated disease, namely, common variable immunodeficiency, IgA deficiency, or giardiasis [2]. NLH generally presents as an asymptomatic disease; diagnosis is made at endoscopy or contrast barium studies and should be confirmed by histology. Treatment is directed at associated conditions, with malignancy being the greatest concern, as NLH has been linked to lymphoma and may be a premalignant disorder [3].