Evaluation of the Effects of Ethanolic Extract of Sesamum Indicum Seeds on Testicular Morphometry of Adult Male Wistar Rats Secondary to Ketoconazole- Induced Damage

Yusuf MK, Ibegbu AO and Alawa JN

Published on: 2025-08-06

Abstract

Aim: The study was aimed at evaluating the effects of ethanolic extract of Sesamum indicum seeds on testicular morphometry in ketoconazole induced damage in Wistar rats.

Methods: Forty eight (48) adult male Wistar rats were divided into eight (8) Groups of six (6) rats each. Groups 1,2,3,4,5,6,7 and 8 were administered 1ml of normal saline, 100 mg/kg body weight (bwt) of Ketoconazole only, 500 mg/kg bwt of ethanolic extract of sesamum indicum (EESI) seeds then100 mg/kg bwt of Ketoconazole,100 mg/kg bwt of Ketoconazole then 250 mg /kg body weight of EESI seeds,100 mg/kg bwt of Ketoconazole then 500 mg/kg bwt of EESI, 100 mg/kg body weight of Ketoconazole then 0.36 mg/kg body weight of Mesterolone, 0.36 mg/kg body weight of Mesterolone,500 mg/kg body weight of EESI respectively. All administrations were carried out orally once per day. The histological slides were prepared for morphometric analyses.

Result: The morphometry of the seminiferous tubules in group 1 and in the groups administered EESI before ketoconazole were significantly increased compared with rats in the Group 2 alone (p ≤ 0.05).

Conclusions: The administration of ethanolic extract of Sesamum indicum appeared to have minimized the distortion of the normal dimensions of the testes caused by ketoconazole which may be due to its androgenic properties.