Impact of Immune Cell Derived Exosome Mimetic Containing I131 Pyruvate Kinase M2on Cold Tumors

Atta WO

Published on: 1970-01-01

Abstract

Tumor derived exosomes play a crucial role in tumor microenvironment for creation appropriate cancer cell niche which will upregulate angiogenesis and spread. Immune cell derived exosome mimetic (IDEM) is one of the most developed therapeutic formsfor treatment different neoplastic types. In result will be translocated to the malignant cell nucleus. Here in my article review, encapsulation of the IDEM with I131- biotin pyruvate kinase M2 , which will undergo translocation to the nucleus as a PKM2 dimer with a nonmetabolic function but a transcription function. It is well known that I 131has the advantage of β rays emission that constitutes a radioactive weapon against cancer cell nucleus by damaging its DNA and releasing reactive oxygen species. It is not forgotten that I 131half life time is about 8 dayswhile beta atoms emission.Carrying I131biotin on PKM2 encapsulated within the IDEM will specify the ionizing irradiation towards the malignant cell nuclei of cold tumors specifically. The benefit from that therapy will be clear and evidenced in cold tumors, if used prior to different immunotherapeutic drugs.