Method of Musico-Kinetic Therapy was developed in clinical practice under the hypothesis that musical and kinetic stimulation, Vertical motions can be said to mainly activate the ceruleus nucleus and is believed to activate, along with sound action, a broad range of neural networks from the amygdaloyd body to the limbic system, including the hippocampus, and to the frontal lobe.

As such, the ceruleus nucleus is most rich in norepinephrine-containing neurons, involves projection control of the brain center, and plays key roles in learning, sedation, urination, blood circulation, and hormone function. On this basis, it is hypothesized that MKT could promote most effectively the restoration of cerebral functions involved in awareness to environmental stimuli in PVS patients. The recent development of neuroscience demonstrated that presence of dynamic center core system (DCC) by Dr. N. Hayashi for integrating mechanism of consciousness, memory, thinking, and mind formation, simultaneously.

Figure 1: Musico-Kinetic therapy activate thinking, mind, memory,and inner consciousness throughout stimulation of dynamic center core system.

Figure 2: Musico-Kinetic therapy activate thinking, mind, memory,and inner consciousness throughout stimulation of dynamic center core system.

In this presentation, the changes of neurotransmitters by MKT for PVS after brain hypothermia treatment was studied.

We have treated MKT for 78 cases of PVS patients. In this treatment, the brain hypothermia intensive care management cases were in counted 8 cases.  One session performed MKT of 30 minutes five times in three days watched value alteration for three weeks of neurohormone and metabolic of the cerebrospinal  fluid (CSF) every one week.

The changes of serum neuro-transmitters such as dopamine, L-3,4-dihydroxyphenylalanine (L-DOPA), 2,4-dihydroxyphenyllacetic acid (DOPAC), serotonine, epinephrine, norepinephrine, prolactin, homovanillic acid (HVA), 3-metoxy-4-hyroxy phenyl ethilen glucol (MHPG), metoxy-phenyl ethylene glycol (MOPEG) were measured at one week interval for one month MKT in 4 cases.

Figure 3: The sequential changes of CSF epinephrine norepinephrine and these metabolic substrates in vegetate state patients by Noda music therapy.

Figure 4: The sequential changes of dopamine, L-DOPHA, HVA and DOPAC in vegetate patients by Noda music therapy.

Figure 5: The sequential changes of amino acids of CSFIN vagetate state patientsby NODA music therapy.

Figure 6: The sequential changes of asparate, glutamate and glutamine in vegetate state patients by Noda music therapy.

Figure 7: The sequential changes of ACTH, estrogen, growth hormone, and Prolactin of CSF in vegetate patients by Noda music therapy.

Figure 8: The sequential changes of 5-hydroxyindoleacetic acid of CSF in vegetate state patients by Noda music therapy.

Figure 9: Changes of epinephrine in CSF.

Elevation of the L-DOPA and HVA which is dopamine metabolic substrate in CSF within at one week suggested good clinical out came.

Late response of CSF-epinephrine at one to two weeks is good indicator for reversibility.

• MKT may stimulate Dopamine central nerve System that is major promoter of DCC function.
• Increased CSF-Epinephrine Norepinephrine suggested responseness of cortex.
• The brain hypothermia treatment protects selective radical of DCC. 
• Therefore, initial protection of DCC by brain hypothermia is important for effectiveness of MKT.

Figure 10: Changes of norepinephrine in CSF.

Figure 11: Brain injury and liver injury by the traffic accident.

Figure 12: Brain injury by violence.

Figure 13: 69 Years old Female Traumatic brain injury.

Figure 14: 65 year old female traumatic brain injury.

Figure 15: Changes of beta endorphin in cerebrospinal fluid.

Figure 16: Changes of met-enkephalin in cerebrospinal fluid.

• The β-endorphin concentrations are low in all patients.
• When musico-kinetic therapy is provided, cerebrospinal fluid levels rise.
• As for the case that there was not so a clinical response, β-endorphin concentrations do not remain.
• Concentrations rise, and pre-2nd becomes the normal range from Pre-1st.

The reason that beta-endorphin and Met-enkephalin produce is caused by a hypothalamic response detect a gravity change. Increase of epinephrine, norepinephrine and the dopamine is the response. A gravity change and the stimulation of the music make consciousness awakening and a mind revive.

MKT could promote most effectively the restoration of cerebral functions and produces β-endorphin, methionine enkephalin to promotes restoration of a nerve injury part and reorganization of nervous system.

Finally I want to say that it should begin a MKT therapy early. I think this treatment must be started from subacute period especially within 60 days from the onset. However, it is good that we took this MKT therapy without giving it up even if the patients start few years later.  One of the most important and useful method that we can make the patients with disturbed consciousness return their social life is a corporation of brain hypothermia and Musico Kinetic Therapy.