Hypophosphatemia In Renal Transplantation

Dominique M, Mombelli C, Deluca G, Cubas M, Seeber M, Sffaeir S, Aroca-Martinez G and Musso CG

Published on: 2023-07-31

Abstract

Introduction: Phosphorus is a highly required mineral for many relevant cellular functions. Three major organs participate in phosphorus homeostasis: kidney, bone, and intestine, although its homeostasis is mainly maintained through renal excretion of ingested phosphate. In post-renal transplantation (PRT) patients, hypophosphatemia and renal phosphate wasting are common occurrences, and despite they are usually thought as transient in the early post-transplantation, they can persist in time. Even though hyperparathyroidism is known to play a significant role in the development of PRT hypophosphatemia, there should be another mechanism which justifies the development of a renal phosphorus leak in this population, such as phosphatonins increase.

Conclusion: Due to its clinical significance, it is necessary to further define the prevalence and natural history of phosphorus wasting and negative balance in PRT population.