Common Neurodegenerative Etiology of Diabetes and Alzheimer’s disease (AD) As Type 3 Diabetes (T3D)

Bando H

Published on: 2024-08-19

Abstract

Type 2 diabetes (T2D) has been a crucial disease, and its prevalence and incidence are increasing worldwide. Alzheimer’s disease (AD) is significant comorbidity of T2D, and the risk of AD would be 1.4--2.0-fold increase among T2D cases. T2D and AD increase with aging, associated with common etiologic factors and genetic components. Biochemical and molecular factors may contribute energy metabolism, impaired brain glucose utilization, insulin signaling and so on. Then, AD has been considered as type 3 diabetes (T3D) or brain diabetes. Parkinson’s disease (PD) is also involved in impaired diabetic mechanism, and future research include T2D, AD and PD.