Deciphering the Pathogenesis of Staphylococcus Aureus: Understanding Its Relationship with Human Skin
Nisar Abbasi S, Malik Z and Zubair K
Published on: 2024-07-20
Abstract
A dangerous human pathogen known for its capacity to colonize and cause a variety of diseases, especially on human skin, is Staphylococcus aureus. Staphylococcus aureus, commensal of human skin is a dynamic pathogen known to cause a number of skin infections from minor skins ailments to life-threatening systemic diseases. It is very crucial to analyze the relationship of this notorious pathogen with its host as to bring novelty in therapeutic interventions. Furthermore, S.aureus also has capacity to secrete factors like CHIPS (chemo taxis inhibitory protein of Staphylococcus aureus) and Extracellular adherence protein that inhibit the activity of neutrophils. This review will be an overview of Staphylococci:
- Colonization
- Invasion
- Pathogenesis
- Virulence factors
- Host defense system against the pathogen
Additionally the therapeutic interventions will be discussed and later on antibiotic resistance will be targeted.