# Mathematical Formulae That Validate the Germ Terrain Duality Theory; the Comparative Size of the Immanent Cellular Dust [Microzymas]

Published on: 2021-03-29

#### Abstract

Drug dosages, whether calculated via the ratio (rainbow), proportion, formulae or dimensional analysis method are determined by various factors. These factors include the weight of the patient and the route of administration. Both weight and route of drug administration are terrain related parameters [1].s.

#### Keywords

Cellular dust; Germ

#### Commentary

The Germ-Terrain duality theory of disease states that the etiology of certain diseases/diseased states is better explained as a complex interplay between germs and the inherent anatomical/physiological integrity of the body cells.It argues that the etiology of certain diseases is not fully explained merely by the presence of germs (Germ Theory) or by a mere loss of cellular integrity (Terrain Theory). As a result the prevention and treatment of such diseases should focus not just on fighting germs but on maintaining/restoring the anatomical/physiological cellular integrity. The Germ-Terrain duality theory is a harmonization of the current Germ Theory (popularized by Loius Pasteur) and the hitherto discarded Terrain Theory (popularized by Pierre Bechamp) [1-2]. The oral terrain [tablets, capsules and syrups] - ph 5.7 to 7 -is anatomically and chemically different from the venous [hypodermic injection] - ph 7.4 or anal [suppositories] -ph 6.7 terrain. The mathematical formulae for calculating drug dosages and infusion rates thus validate the germ terrain duality theory viz Cockcroft and Gaunt equations, Clarke’s Rule and Young’s Law, the first and second generation Daugiradas formula for haemodialysis etcetera. Clarke’s Rule: child's weight in pounds, divided by 150 pounds, and the result multiplied by the adult dose to find the equivalent children dosage. Parkland Formula for total fluid requirement in 24 hours is 4ml multiplied by total body surface area. Cockcroft and Gaunt formula is (140 - age) (weight in kg)/ 72 × serum creatinine for men and the same multiplied by 0.85 for women. Daugirdas mathematical formula is Kt/V = -ln (R – 0.03) + [(4 – 3.5R) x (UF ÷ W)]

Where W= post dialysis weight in kg

What is the relative size of the immanent cellular dust (maximum size 500 nanometer) viz a viz other more widely known minuscule and microscopic entities? [3] There are 25,400,000 nanometer in one inch.

Table 1: the most important drugs ever invented in the last 100 plus years and the discipline/profession/occupation of the inventors and discoverers.

 Drug Inventor Discipline Insulin Sir Frederick Grant Banting Orthopaedic surgery Levothyroxine Charles Harington Chemical Pathology Penicillin Alexander Fleming Medicine, Microbiology Prontosil Gerhard Domagk Medicine Cortisone Edward Calvin Kendall Philip Showalter Hench Chemistry Medicine Lidocaine Nils Löfgren Chemistry Lysergic acid diethylamide (LSD) Albert Hofmann Chemistry Chlordiazepoxide Leo Sternbach Chemistry Furosemide Calvin L. Stevens Chemistry Ketamine Calvin L. Stevens Chemistry Phenylhydrazine Emil Fischer Chemistry Paracetamol Harmon Northrop Morse Chemistry Phenazone Ludwig Knorr Chemistry Benzocaine August Bischler Chemistry Quinazoline August Bischler Chemistry Amphetamine Laz?r Edeleanu Chemistry Adrenaline Takamine J?kichi Chemistry Arsphenamine Alfred Bertheim Chemistry Vitamin C Tadeusz Reichstein Chemistry Oxytocin Henry Hallett Dale Medicine Phenytoin Heinrich Biltz Chemistry, Natural Science Phenobarbital Joseph von Mering Franz Joseph Emil Fischer Medicine Chemistry Thyroxine Edward Calvin Kendall Chemistry Ergotamine Arthur Stoll Chemistry Viagra Ian Osterloh Robert Francis Furchgott Peter Dunn Nicholas Terrett Medicine and Surgery Biochemistry Chemistry Chemistry

#### References

1. Ayoade MS. A New Natural Law Proposed. SALLT. Anesthesiologist. 2019; 1: 1002.
2. Ayoade MS. Please Patiently Pick Per Person-Pedadogue, Pretender, Plagiartist, Pilferer. Biomedical Journal of Scientific & Technical Research, Bio Res Net. LLC. 2019; 16: 12380-12382.
3. Seun A. A New Origin of Life and the Universe Proposed-Microzymian! Peer Re J Foren & Gen Sci. 2018; 1.
4. Ayoade S. Microzyman Theory of Origin (MTO)/ Cellular Dust Hypothesis (CDH)-Matters Arising. Peer Rev J Of For & Gen Sci. Lupine Publishers. LLC, 2018; 2: 142-143.
5. Ayoade S. Koch’s Postulates and Germ Terrain Dualism; Cellular Dust as Yet another Term for Microzymas. J Mol Genet Med. 2017; 11: 297.
6. Ayoade S. Isaac Newton’s Active Principles, Particles and the Cellular Dust Hypothesis. Rewriting Cytology and Histology in the Light of SAMS. 2020.