The Germ-Terrain duality theory of disease states that the etiology of certain diseases/diseased states is better explained as a complex interplay between germs and the inherent anatomical/physiological integrity of the body cells.It argues that the etiology of certain diseases is not fully explained merely by the presence of germs (Germ Theory) or by a mere loss of cellular integrity (Terrain Theory). As a result the prevention and treatment of such diseases should focus not just on fighting germs but on maintaining/restoring the anatomical/physiological cellular integrity. The Germ-Terrain duality theory is a harmonization of the current Germ Theory (popularized by Loius Pasteur) and the hitherto discarded Terrain Theory (popularized by Pierre Bechamp) [1-2]. The oral terrain [tablets, capsules and syrups] - ph 5.7 to 7 -is anatomically and chemically different from the venous [hypodermic injection] - ph 7.4 or anal [suppositories] -ph 6.7 terrain. The mathematical formulae for calculating drug dosages and infusion rates thus validate the germ terrain duality theory viz Cockcroft and Gaunt equations, Clarke’s Rule and Young’s Law, the first and second generation Daugiradas formula for haemodialysis etcetera. Clarke’s Rule: child's weight in pounds, divided by 150 pounds, and the result multiplied by the adult dose to find the equivalent children dosage. Parkland Formula for total fluid requirement in 24 hours is 4ml multiplied by total body surface area. Cockcroft and Gaunt formula is (140 - age) (weight in kg)/ 72 × serum creatinine for men and the same multiplied by 0.85 for women. Daugirdas mathematical formula is Kt/V = -ln (R – 0.03) + [(4 – 3.5R) x (UF ÷ W)]

Where W= post dialysis weight in kg

What is the relative size of the immanent cellular dust (maximum size 500 nanometer) viz a viz other more widely known minuscule and microscopic entities? [3] There are 25,400,000 nanometer in one inch.  

Table 1: the most important drugs ever invented in the last 100 plus years and the discipline/profession/occupation of the inventors and discoverers.

1. Ayoade MS. A New Natural Law Proposed. SALLT. Anesthesiologist. 2019; 1: 1002.
2. Ayoade MS. Please Patiently Pick Per Person-Pedadogue, Pretender, Plagiartist, Pilferer. Biomedical Journal of Scientific & Technical Research, Bio Res Net. LLC. 2019; 16: 12380-12382.
3. Seun A. A New Origin of Life and the Universe Proposed-Microzymian! Peer Re J Foren & Gen Sci. 2018; 1.
4. Ayoade S. Microzyman Theory of Origin (MTO)/ Cellular Dust Hypothesis (CDH)-Matters Arising. Peer Rev J Of For & Gen Sci. Lupine Publishers. LLC, 2018; 2: 142-143.
5. Ayoade S. Koch’s Postulates and Germ Terrain Dualism; Cellular Dust as Yet another Term for Microzymas. J Mol Genet Med. 2017; 11: 297.
6. Ayoade S. Isaac Newton’s Active Principles, Particles and the Cellular Dust Hypothesis. Rewriting Cytology and Histology in the Light of SAMS. 2020.