Periodontal Condition in Patients with Glioblastoma: A Case-Control Study

Chrysanthakopoulos NA and Chrysanthakopoulos PA

Published on: 2019-10-16

Abstract

Aim: The aim of the present study was to estimate the possible differences regarding the periodontal condition between individuals suffering from glioblastoma multiform (GBM) or di?use astrocytoma, WHO grade Ivdiagnosed by histological examinations after performing the surgical removal of the tumor and non-glioblastoma individuals.

Methods: 77 individuals with GBM and 150 matching healthy controls were interviewed and oral clinically examined. The indices used to determine the periodontal condition for cases and controls included Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Gingival Index (GI). Chi-square test and logistic regression models were performed to estimate the data.

Results: Patients with GBM showed a significantly high percentage of periodontal indices compared with controls. GBM patients showed worst periodontal indices among some of the indices examined such as CAL (p = 0.001) and GI (p = 0.04) after adjustment for smoking and socio-economic status.

Conclusions: Clinical attachment loss and gingival inflammation were statistically significantly different between patients who were suffered from GBM and healthy individuals.