Van Wyk–Grumbach Syndrome in a Child: A Rare and Reversible Cause of Precocious Puberty

Ambekar AN, Sonwane AC, Dhaneria S, Kandula S, Sethi BK and Modi KD

Published on: 2025-07-11

Abstract

Van Wyk-Grumbach syndrome is characterized by a constellation of findings such as vaginal bleeding, multicystic ovaries, and delayed bone age due to long-standing untreated hypothyroidism in a prepubertal girl child [1]. We report a case of 10.2 years old girl child presented with abdominal pain and two episodes of vaginal bleeding. Surgery was planned due to multicystic ovaries and an elevated CA125 level. On evaluation, her TSH was elevated with low free T4, and she had typical features of hypothyroidism. Her LH was prepubertal with marginally high FSH. She was started on a thyroxine supplement and asked for a follow-up. Her TSH was normalized, along with the resolution of cysts. Identification of this rare entity is necessary to prevent unnecessary intervention.