A Review on Nano-Emulgel as a Novel Carrier for Topical Drug Delivery System

Shilpa Y and Ravi K

Published on: 2023-12-27

Abstract

Nano-emulgel, a new transdermal delivery method, has demonstrated unexpected advantages for lipophilic medicines over conventional formulations. Because most contemporary medications introduced in this modern period are lipophilic, they have poor oral bioavailability, irregular absorption, and variable pharmacokinetics. In order to prevent such disruptions, it has been demonstrated that this innovative transdermal delivery method is superior to traditional oral and topical drug delivery methods. These nanoemulgel are essentially gelled oil-in-water nano-emulsions that have been mixed with a gelling agent. The new technique created by adding nano-emulsion to gel increases stability and permits quick and regulated release of the medicine. In addition, it can prevent first-pass metabolism, alleviate the user of gastric or systemic incompatibilities, and be more precisely targeted to the site of action. The new system created by adding nano-emulsion to gel enhances stability and permits controlled and immediate release of medication. Because of its safety profile, lack of gastrointestinal breakdown or first-pass metabolism, ease of application, and capacity for targeted delivery, nano-emulgel has also gained more attention. This review focused on the formulation components, preparation, and characterization of nanoemulgel.