Eco - Friendly Method for the Estimation of Bisacodyl in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing

Ahmed NR and Al-Etewi MJE

Published on: 2023-10-10

Abstract

 A simple, precise, accurate, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of Bisacodyl in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 263 nm in ethanol (95%). Beer's law was obeyed in the range of 2.5-60μg/ ml, with molar absorptivity of 5. 3 ×10³ L.mol^-1.cm^-1, relative standard deviation of the method was less than 1.8%, and accuracy (average recovery %) was 100 ± 1.0. The method was successfully applied to the determination of Bisacodyl in some pharmaceutical formulations (Tablets) and in environmental water samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Bisacodyl in true samples.