Clinical Response of Syrup Hydryllin® in Pakistani Subjects with Cough in Routine Practice “HYD-EFFECT”

Ismail QR, Saadiq AS, Mahmud TR, Ali SA, Mujtaba M, Mansoor S, Fatima A, Memon MH, Samad A, Sumit AR and Farooq YS

Published on: 2024-11-07

Abstract

Background: Cough, a basic reflex, can evolve into a strong adversary, impacting both an individual’s quality of life (QoL) and the healthcare system. Cough syrups, often seen as a supporting remedy reducing the frequency of coughs, alleviate discomfort and improve quality of life.

Objectives: The current study aimed to assess the clinical response of syrup Hydryllin® (diphenhydramine, ammonium chloride, menthol, and aminophylline) to Pakistani subjects with cough in routine Pakistani practice and its impact on improving the patient’s quality of life (QoL).

Design: A prospective, observational, cohort, multicenter study (HYD-EFFECT).

Methods: Two hundred and seventy patients (adults) both gender (male and female) with age 18 to 70 years, with known prescreened complaints of cough (acute, sub-acute, and chronic) were recruited from 05 major healthcare facilities across two (2) major cities in Sindh, Pakistan, as per the inclusion/exclusion criteria. Following the baseline visit (Visit 1), the physician followed up with the patients 1-2 weeks (Visit 2) after the treatment, at their discretion. The Case Report Form (CRF) for data collection, and it also monitored adverse events (AEs) to assess drug safety. We assessed cough intensity using a visual analogue scale (VAS) and quality of life (QoL) using the Leicester Cough Questionnaire (LCQ).

Results: The total number of cases was 270, with a mean age of 43.73±14.10 years. 119 (44.1%) of the cases had a dry or tickly cough. 191 (70.7%) had a cough for less than three weeks. In 178 (65.9%) cases, the cough intensity was moderate, and 2 (.7%) cases had the worst cough. The overall Leicester score pre-treatment was 82.43±21.8, which changed to 118.58±6.17 (p-value<0.05), which shows improvement in the overall patient's cough condition and quality of life. On the second follow-up visit, there were 151 (55.9%) cases recovered from cough, and 101 (37.4%) responded that they had improved. Among the various strengths of the study, medicine demonstrates that all three medication strengths have an impact on cough improvement. The impact of gender on the treatment response, as measured by the Leicester QoL score, shows significant differences in the mean score from baseline, indicating improvement in both genders. We observed the same pattern for the age and weight of the cases. Furthermore, we observed an overall improvement in the patient's quality of life. During the study, only ten (3%) patients reported mild adverse events (AEs). Conclusion: The Hydryllin® cough syrup demonstrated effective cough management and improved their quality of life.